Thyroid Hormone Deiodinases and Receptors Are Expressed in Human Endothelial Cells

Publication Type:

Journal Article

Authors:

Laura Sabatino; Silvana Balzan; Valter Lubrano; Giorgio Iervasi

Source:

Biomed Data J., Volume 1, Issue 2, p.19-25 (2015)

Keywords:

deiodinases, endothelial cells, Thyroid hormones

Abstract:

The endothelial system acts as a large endocrine organ in the human body, however, little is still known about the regulative role of THs on endothelial cells. The present study aims to investigate the expression of the TH de­iodinases (D1, D2, D3) and TH receptors (TRα1, TRα2 and TRβ1) in an endothe­lial microvascular cultured cell model (HMEC-1), after stimulation with triiodo­thyronine (T3, 10-100nM), thyroxine (T4, 10-100nM), and reverse T3 (rT3, 1-10nM). The main result of the study is that the TH deiodinases and receptors are expressed in endothelial HMEC-1 cells. These findings might be of signifi­cant clinical relevance, given the important regulatory role of the endothelium as first barrier to the bloodstream.

Full text: 

TH Deiodinases Expressed in Human Endothelial Cells
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National Library of Medicine (brackets, no "et al."): Sabatino L, Balzan S, Lubrano V, Iervasi G. Thyroid Hormone Deiodinases and Receptors Are Expressed in Human Endothelial Cells. Biomed Data J. 2015;1(2):19-25.
National Library of Medicine (grant proposals with PMCID/PMID): Sabatino L, Balzan S, Lubrano V, Iervasi G. Thyroid Hormone Deiodinases and Receptors Are Expressed in Human Endothelial Cells. Biomed Data J. 2015;1(2):19-25.
National Library of Medicine (NLM) - Grant with PMID: Sabatino L, Balzan S, Lubrano V, Iervasi G. Thyroid Hormone Deiodinases and Receptors Are Expressed in Human Endothelial Cells. Biomed Data J. 2015;1(2):19-25.
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