Circulatory Modelling as a Clinical Decision Support and an Educational Tool

Publication Type:

Journal Article

Authors:

Gianfranco Ferrari; Arianna Di Molfetta; Krzysztof Zieliński; Libera Fresiello

Source:

Biomed Data J., Volume 1, Issue 3, p.45-50 (2015)

Keywords:

cardiovascular system, Circulatory Model, Clinical Decision Support, Lumped Parameter, Training and Education, ventricular assist device

Abstract:

Circulatory models can be used in support of clinical decision making. Based on this assumption, we developed a modelling platform composed of a family of circulatory models based on a polymorphic structure. The models of the family permit the reconstruction of patient’s status in various pathophysiological conditions and can be used in retrospective and prospective ways to formulate hypotheses on the effects of different therapeutic strategies, including the use of mechanical circulatory assistance, mono and bi-ventricular pacing and con­genital heart defects. The models can be used for educational purposes, can be controlled remotely and can behave as virtual patients. They can generate data files in Excel format.

Full text: 

Circulatory Modelling for Clinical Decision Support and Education
Pepper JR. Update on mechanical circulatory support in heart failure. Heart. 2012;98(8):663 - 669.
Kirklin JK, Naftel DC, Pagani FD, Kormos RL, Stevenson L, Miller M, Young JB. Long-term mechanical circulatory support (destination therapy): On track to compete with heart transplantation?. The Journal of Thoracic and Cardiovascular Surgery. 2012;144(3):584 - 603.
Gingrich KJ, Roy RJ. Modeling the hemodynamic response to dopamine in acute heat failure. IEEE Transactions on Biomedical Engineering. 1991;38(3):267 - 272.
Heldt T, Mukkamala R, Moody GB, Mark RG. CVSim: An Open-Source Cardiovascular Simulator for Teaching and Research. Open Pacing Electrophysiol Ther J. 2010;3:45-54.
Goodwin JA, van Meurs WL, Couto CDSá, Beneken JEW, Graves SA. A Model for Educational Simulation of Infant Cardiovascular Physiology. Anesthesia & Analgesia. 2004;:1655 - 1664.
Tokaji M, Ninomiya S, Kurosaki T, Orihashi K, Sueda T. An Educational Training Simulator for Advanced Perfusion Techniques Using a High-Fidelity Virtual Patient Model. Artificial Organs. 2012;36(12):1026 - 1035.
Ferrari G, Kozarski M, Gu YJ, De Lazzari C, Di Molfetta A, Palko KJ, Zieliński K, Górczynska K, Darowski M, Rakhorst G. Application of a user-friendly comprehensive circulatory model for estimation of hemodynamic and ventricular variables. Int J Artif Organs. 2008;31(12):1043-54.
Fresiello L, Ferrari G, Di Molfetta A, Zieliński K, Tzallas A, Jacobs S, Darowski M, Kozarski M, Meyns B, Katertsidis NS, Karvounis EC, Tsipouras MG, Trivella MG. A cardiovascular simulator tailored for training and clinical uses. Journal of Biomedical Informatics. 2015;57:100 - 112.
Di Molfetta A, Jacobs S, Fresiello L, Verbelen T, Trivella MG, Meyns B, Ferrari G. Simulation of apical and atrio-aortic VAD in patients with transposition or congenitally corrected transposition of the great arteries. The International Journal of Artificial Organs. 2014;1(37):58 - 70.
Di Molfetta A, Pilati M, Gagliardi MG, Fresiello L, Amodeo A, Cristofaletti A, Pongiglione G, Ferrari G. Tailoring the hybrid palliation for hypoplastic left heart syndrome: A simulation study using a lumped parameter model. Medical Engineering & Physics. 2015;37(9):898 - 904.
Di Molfetta A, Amodeo A, Fresiello L, Trivella MGiovanna, Iacobelli R, Pilati M, Ferrari G. Simulation of Ventricular, Cavo-Pulmonary, and Biventricular Ventricular Assist Devices in Failing Fontan. Artificial Organs. 2015;39(7):550 - 558.
Ferrari G, Khir AW, Fresiello L, Di Molfetta A, Kozarski M. Hybrid Model Analysis of Intra-Aortic Balloon Pump Performance as a Function of Ventricular and Circulatory Parameters. Artificial Organs. 2011;35(9):902 - 911.
Di Molfetta A, Santini L, Forleo GB, Cesario M, Tota C, Sgueglia M, Sergi D, Ferrari G, Romeo F. Use of a comprehensive numerical model to improve biventricular pacemaker temporization in patients affected by heart failure undergoing to CRT-D therapy. Medical & Biological Engineering & Computing. 2010;48(8):755 - 764.
Mahmood MNauzef, Fresiello L, Di Molfetta A, Ferrari G. A modeling tool to study the combined effects of drug administration and LVAD assistance in pathophysiological circulatory conditions. The International Journal of Artificial Organs. 2014;37(11):824 - 833.
Ferrari G, Kozarski M, De Lazzari C, Clemente F, Merolli M, Tosti G, Guaragno M, Mimmo R, Ambrosi D, Glapinski J. A hybrid (numerical-physical) model of the left ventricle. Int J Artif Organs. 2001;24(7):456-62.
Kozarski M, Ferrari G, Zieliński K, Górczyńska K, Pałko KJ, Tokarz A, Darowski M. A new hybrid electro-numerical model of the left ventricle. Computers in Biology and Medicine. 2008;38(9):979 - 989.
Maciej K, Gianfranco F, Krzysztof Z, Krystyna G, J. PKrzysztof, Libera F, Arianna DMolfetta, Marek D. A Hybrid (Hydro-numerical) Cardiovascular Model: Application to Investigate Continuous-flow Pump Assistance Effect. Biocybernetics and Biomedical Engineering. 2012;32(4):77 - 91.
Darowski M, Kozarski M, Ferrari G, Zieliński K, Górczyńska K, Szczepanowski A, Pałko KJ, Fresiello L, Di Molfetta A. A new hybrid (hydro-numerical) model of the circulatory system. Bulletin of the Polish Academy of Sciences: Technical Sciences. 2013;61(4).
Fresiello L, Zieliński K, Jacobs S, Di Molfetta A, Pałko KJakub, Bernini F, Martin M, Claus P, Ferrari G, Trivella MGiovanna, Górczyńska K, Darowski M, Meyns B, Kozarski M. Reproduction of Continuous Flow Left Ventricular Assist Device Experimental Data by Means of a Hybrid Cardiovascular Model With Baroreflex Control. Artificial Organs. 2014;38(6):456 - 468.
Di Molfetta A, Ferrari G, Filippelli S, Fresiello L, Iacobelli R, Gagliardi MG, Amodeo A. Use of Ventricular Assist Device in Univentricular Physiology: The Role of Lumped Parameter Models. Artificial Organs. 2015;:n/a - n/a.
Di Molfetta A, Amodeo A, Fresiello L, Filippelli S, Pilati M, Iacobelli R, Adorisio R, Colella D, Ferrari G. The use of a numerical model to simulate the cavo-pulmonary assistance in Fontan circulation: a preliminary verification. Journal of Artificial Organs. 2015;.
Di Molfetta A, Amodeo A, Gagliardi MG, Trivella MG, Fresiello L, Filippelli S, Toscano A, Ferrari G. Hemodynamic Effects of Ventricular Assist Device Implantation on Norwood, Glenn, and Fontan Circulation: A Simulation Study. Artificial Organs. 2016;40(1):34 - 42.
Korakianitis T, Shi Y. A concentrated parameter model for the human cardiovascular system including heart valve dynamics and atrioventricular interaction. Medical Engineering & Physics. 2006;28(7):613 - 628.
Di Molfetta A, Santini L, Forleo GB, Minni V, Mafhouz K, Rocca DGDella, Fresiello L, Romeo F, Ferrari G. Towards a Personalized and Dynamic CRT-D. Methods of Information in Medicine. 2012;51(6):495 - 506.
Fresiello L, Khir AWilliam, Di Molfetta A, Kozarski M, Ferrari G. Effects of Intra-Aortic Balloon Pump Timing on Baroreflex Activities in a Closed-Loop Cardiovascular Hybrid Model. Artificial Organs. 2013;37(3):237 - 247.
National Library of Medicine (brackets, no "et al."): Ferrari G, Di Molfetta A, Zieliński K, Fresiello L. Circulatory Modelling as a Clinical Decision Support and an Educational Tool. Biomed Data J. 2015;1(3):45-50.
National Library of Medicine (grant proposals with PMCID/PMID): Ferrari G, Di Molfetta A, Zieliński K, Fresiello L. Circulatory Modelling as a Clinical Decision Support and an Educational Tool. Biomed Data J. 2015;1(3):45-50.
National Library of Medicine (NLM) - Grant with PMID: Ferrari G, Di Molfetta A, Zieliński K, Fresiello L. Circulatory Modelling as a Clinical Decision Support and an Educational Tool. Biomed Data J. 2015;1(3):45-50.
I acknowledge that I have read, understand, and accept these conditions for using the dataset(s).
28,117 times
# File Name Number of Downloads
1 bmdj.01303_Circulatory_modelling.pdf 6331
2 01303_Cardiocirculatory_pathologies.ods 1943
3 01303_Cardiocirculatory_pathologies.xlsx 2147
(1)
Share