A cellular automata model of enzyme kinetics.

Publication Type:

Journal Article

Authors:

Kier, L B; Cheng, C K; Testa, B; Carrupt, P A

Source:

J Mol Graph, Volume 14, Issue 4, p.227-31, 226 (1996)

Keywords:

Automation, Computer Simulation, Enzymes, Kinetics, Models, Chemical

Abstract:

<p>We have developed a cellular automata model of an enzyme reaction with a substrate in water. The model produces Michaelis-Menten kinetics with good Lineweaver-Burk plots. The variation in affinity parameters predicts that, in general, hydrophobic substrates are more reactive with enzymes, this attribute being more important than the relationship between enzyme and substrate. The ease of generation and the illustrative value of the model lead us to believe that cellular automata models have a useful role in the study of dynamic phenomena such as enzyme kinetics.</p>

National Library of Medicine (brackets, no "et al."): Kier LB, Cheng CK, Testa B, Carrupt PA. A cellular automata model of enzyme kinetics. J Mol Graph. 1996;14(4):227-31, 226.
National Library of Medicine (grant proposals with PMCID/PMID): Kier LB, Cheng CK, Testa B, Carrupt PA. A cellular automata model of enzyme kinetics. J Mol Graph. 1996;14(4):227-31, 226.
National Library of Medicine (NLM) - Grant with PMID: Kier LB, Cheng CK, Testa B, Carrupt PA. A cellular automata model of enzyme kinetics. J Mol Graph. 1996;14(4):227-31, 226.
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