RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients. Journal of Cancer Research and Clinical Oncology. 2011;137(9):1349 - 1361. .
RP101 improves the efficacy of chemotherapy in pancreas carcinoma cell lines and pancreatic cancer patients. Anti-Cancer Drugs. 2006;17(9):1045 - 1056. .
Inhibition of induced chemoresistance by cotreatment with (E)-5-(2-bromovinyl)-2'-deoxyuridine (RP101). Cancer Res. 2003;63(18):5745-53. .