Thyroid Hormone Deiodinases and Receptors Are Expressed in Human Endothelial Cells

Publication Type:

Journal Article

Source:

Biomed Data J., Volume 1, Issue 2, p.19-25 (2015)

Keywords:

deiodinases, endothelial cells, Thyroid hormones

Abstract:

The endothelial system acts as a large endocrine organ in the human body, however, little is still known about the regulative role of THs on endothelial cells. The present study aims to investigate the expression of the TH de­iodinases (D1, D2, D3) and TH receptors (TRα1, TRα2 and TRβ1) in an endothe­lial microvascular cultured cell model (HMEC-1), after stimulation with triiodo­thyronine (T3, 10-100nM), thyroxine (T4, 10-100nM), and reverse T3 (rT3, 1-10nM). The main result of the study is that the TH deiodinases and receptors are expressed in endothelial HMEC-1 cells. These findings might be of signifi­cant clinical relevance, given the important regulatory role of the endothelium as first barrier to the bloodstream.

Full text: 

Polikar R, Burger AG, Scherrer U, Nicod P. The thyroid and the heart. Circulation. 1993;87(5):1435 - 1441.
Williams GR. Cloning and Characterization of Two Novel Thyroid Hormone Receptor beta Isoforms. Molecular and Cellular Biology. 2000;20(22):8329 - 8342.
Cheng S-Y, Leonard JL, Davis PJ. Molecular Aspects of Thyroid Hormone Actions. Endocrine Reviews. 2010;31(2):139 - 170.
Visser TJ, Kaptein E, Terpestra OT, Krenning P. Deiodination of Thyroid Hormone by Human Liver. The Journal of Clinical Endocrinology & Metabolism. 1988;67(1):17 - 24.
Martinez-deMena R, Hernández A, Obregón M-J. Triiodothyronine is required for the stimulation of type II 5′-deiodinase mRNA in rat brown adipocytes. American Journal of Physiology - Endocrinology And Metabolism. 2002;282(5):E1119 - E1127.
National Library of Medicine (grant proposals with PMCID/PMID): Sabatino L, Balzan S, Lubrano V, Iervasi G. Thyroid Hormone Deiodinases and Receptors Are Expressed in Human Endothelial Cells. Biomed Data J. 2015;1(2):19-25.
I acknowledge that I have read, understand, and accept these conditions for using the dataset(s).
5,110 times
# File Name Number of Downloads
1 bmdj.01203_Thyroid_hormone_deiodinases.pdf 1238
2 01203_Thyroid_hormone_deiodinases.ods 482
3 01203_Thyroid_hormone_deiodinases.xls 629
(1)
Share