Thyroid Hormone and C-Reactive Protein Serum Concentrations, Disease Severity and Discharge Outcomes of Ischemic Stroke Patients: A Dataset

Publication Type:

Journal Article

Source:

Biomed Data J. , Volume 1, Issue 2, p.13-18 (2015)

Keywords:

C-reactive protein, Ischemic stroke, Neuroprotection, Outcomes, Thyroid hormones

Abstract:

Ischemic stroke remains a serious public health problem, associated with sig­nificant mortality and morbidity. Accurate and timely prognostication of func­tional and patient-oriented outcomes of stroke victims is important for im­proving patient outcomes and for optimized use of healthcare resources. A growing body of evidence suggests that the Hypothalamic-Pituitary-Thyroid axis hormones can exert neuro-protective properties under ischemic condi­tions and can be employed for outcome prediction in severely ill patients, in­cluding stroke victims. The goal of the present study was to investigate the as­sociation of the HPT-axis and C-reactive protein (CRP) serum concentrations with clinical stroke severity and with functional and cognitive discharge out­comes. Here we present a dataset from prospective observational cohort study of 88 acute ischemic stroke patient admitted within 24 hours after stroke symptom onset and without thyroid gland disorders. All patients received treatment according to the existing guidelines. The dataset includes socio-de­mographic and clinical characteristics, clinical stroke severity assessment (Scandinavian Stroke Scale), serum concentrations of tri-iodothyronine, thy­roxin, thyroid stimulating hormone and CRP that were evaluated within 24 hours after hospital admission. Functional outcome (modified Rankin scale) and cognitive outcome (Mini Mental State Examination) assessments were performed at hospital discharge. Interested readers can download both the paper and the dataset it describes below, under the respective Creative Commons licence.

Full text: 

Jickling GC, Sharp FR. Blood Biomarkers of Ischemic Stroke. Neurotherapeutics. 2011;8(3):349 - 360.
Farwell AP. Nonthyroidal illness syndrome. Current Opinion in Endocrinology & Diabetes and Obesity. 2013;20(5):478 - 484.
Leonard JL, Koehrle J. Intracellular pathways of iodothyronine metabolism. Philadelphia, Pennsylvania , USA: Lippincott-Raven Publishers; 1996.
Leonard JK. Intracellular pathways of iodothyro-nine metabolism. In Werner I, ed. The thyroid: A fundamental and clinical text . 7thth ed. Philadelphia: Lippincott-Raven Publishers; 1996. pp. 136-73.
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# File Name Number of Downloads
1 bmdj.01204_Thyroid_Hormone_Ischemic_Stroke.pdf 1909
2 01204_Stroke_Bunevicius.xlsx 795
3 01204_Stroke_Bunevicius.ods 650
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