Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis.

Publication Type:

Journal Article

Source:

Int J Dev Biol, Volume 42, Issue 7, p.995-1002 (1998)

Keywords:

Animals, Apoptosis, Cell Division, Cell Transformation, Neoplastic, Disease Models, Animal, Disease Progression, Humans, Mice, Mice, Knockout, Mice, Transgenic, Neoplasms, Neoplasms, Experimental, Neovascularization, Pathologic

Abstract:

The epidemiology and histopathology of human cancers and studies of animal models of tumorigenesis have led to a widely-accepted notion that multiple genetic and epigenetic changes have to accrue for the successful development of a malignant phenotype. Tumor growth and expansion requires an ability not only to proliferate, but also to down-modulate cell death (apoptosis) and activate angiogenesis to produce a tumor neovasculature. This review will describe the interplay between apoptosis and proliferation, as well as the characteristics of the angiogenic phenotype in two transgenic mouse models of multi-step tumorigenesis, namely, pancreatic islet cell carcinomas and squamous cell carcinomas of the skin.
National Library of Medicine (grant proposals with PMCID/PMID): Bergers G, Hanahan D, Coussens LM. Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis. Int J Dev Biol. 1998;42(7):995-1002.
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